Two of the most encouraging and rigorous studies utilized the RehaCom® software package. (...) It is notable that the RehaCom® package incorporates components that have contributed to the efficacy of other rehabilitation techniques, including repeated stimulation, intensity of training, adjusting task difficulty to the patient’s performance, feedback, therapist involvement, and simulated functional tasks.

RehaCom treatment was associated with increased fMRI activation in the posterior cingulate cortex, precuneus and dorsolateral prefrontal cortex128, indicating that benefit from RehaCom cognitive rehabilitation in people with MS occurs through enhanced recruitment of brain networks subserving the trained functions.

Based on practice guidelines used by the Cognitive Rehabilitation Task Force of the American Congress of Rehabilitation Medicine Brain Injury Interdisciplinary Special Interest Group, Goverover and colleagues [33] recommended (...)  the APT and the RehaCom® as Practice Guidelines (with well designed class II studies) to treat impairments in attention and multiple cognitive domains (attention, information processing speed, executive functioning, and memory), respectively.

RehaCom® was the device more widely tested, especially in patients with MS. The high number of studies increased the variability of the adopted protocols, with a duration of the intervention going from 5 to 15 weeks (each session ranged between 30 and 60 min). However, literature on this device reports solid statistically significant results about its efficacy also when compared to conventional interventions.